Grisactin Ultra
Brand names,
Grisactin Ultra
Analogs
Grisactin Ultra
Brand Names Mixture
Grisactin Ultra
Chemical_Formula
C17H17ClO6
Grisactin Ultra
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Grisactin Ultra
fda sheet
Grisactin Ultra
msds (material safety sheet)
Grisactin Ultra
Synthesis Reference
No information avaliable
Grisactin Ultra
Molecular Weight
352.766 g/mol
Grisactin Ultra
Melting Point
220 oC
Grisactin Ultra
H2O Solubility
8.64 mg/L
Grisactin Ultra
State
Solid
Grisactin Ultra
LogP
2.15
Grisactin Ultra
Dosage Forms
Powder; Tablet
Grisactin Ultra
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Grisactin Ultra
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Grisactin Ultra
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Grisactin Ultra
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Grisactin Ultra
Patient Information
Grisactin Ultra
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi