Grysio
Brand names,
Grysio
Analogs
Grysio
Brand Names Mixture
Grysio
Chemical_Formula
C17H17ClO6
Grysio
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Grysio
fda sheet
Grysio
msds (material safety sheet)
Grysio
Synthesis Reference
No information avaliable
Grysio
Molecular Weight
352.766 g/mol
Grysio
Melting Point
220 oC
Grysio
H2O Solubility
8.64 mg/L
Grysio
State
Solid
Grysio
LogP
2.15
Grysio
Dosage Forms
Powder; Tablet
Grysio
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Grysio
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Grysio
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Grysio
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Grysio
Patient Information
Grysio
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi