Grisetin
Brand names,
Grisetin
Analogs
Grisetin
Brand Names Mixture
Grisetin
Chemical_Formula
C17H17ClO6
Grisetin
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Grisetin
fda sheet
Grisetin
msds (material safety sheet)
Grisetin
Synthesis Reference
No information avaliable
Grisetin
Molecular Weight
352.766 g/mol
Grisetin
Melting Point
220 oC
Grisetin
H2O Solubility
8.64 mg/L
Grisetin
State
Solid
Grisetin
LogP
2.15
Grisetin
Dosage Forms
Powder; Tablet
Grisetin
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Grisetin
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Grisetin
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Grisetin
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Grisetin
Patient Information
Grisetin
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi