Delmofulvina
Brand names,
Delmofulvina
Analogs
Delmofulvina
Brand Names Mixture
Delmofulvina
Chemical_Formula
C17H17ClO6
Delmofulvina
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Delmofulvina
fda sheet
Delmofulvina
msds (material safety sheet)
Delmofulvina
Synthesis Reference
No information avaliable
Delmofulvina
Molecular Weight
352.766 g/mol
Delmofulvina
Melting Point
220 oC
Delmofulvina
H2O Solubility
8.64 mg/L
Delmofulvina
State
Solid
Delmofulvina
LogP
2.15
Delmofulvina
Dosage Forms
Powder; Tablet
Delmofulvina
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Delmofulvina
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Delmofulvina
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Delmofulvina
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Delmofulvina
Patient Information
Delmofulvina
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi