Gresfeed
Brand names,
Gresfeed
Analogs
Gresfeed
Brand Names Mixture
Gresfeed
Chemical_Formula
C17H17ClO6
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RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
352.766 g/mol
Gresfeed
Melting Point
220 oC
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H2O Solubility
8.64 mg/L
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State
Solid
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LogP
2.15
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Dosage Forms
Powder; Tablet
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Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
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Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Gresfeed
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
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side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
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Patient Information
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Organisms Affected
Yeast and other Trichophyton or Microsporum fungi