PharmacyCodes



Cisplatin en es it fr

Cisplatin Brand names, Cisplatin Analogs

Cisplatin Brand Names Mixture

  • No information avaliable

Cisplatin Chemical_Formula

Cl2H4N2Pt

Cisplatin RX_link

http://www.rxlist.com/cgi/generic3/cisplatin.htm

Cisplatin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=71

Cisplatin msds (material safety sheet)

Cisplatin MSDS

Cisplatin Synthesis Reference

No information avaliable

Cisplatin Molecular Weight

298.029 g/mol

Cisplatin Melting Point

270 oC

Cisplatin H2O Solubility

2530 mg/L

Cisplatin State

Solid

Cisplatin LogP

-2.19

Cisplatin Dosage Forms

Solution

Cisplatin Indication

For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.

Cisplatin Pharmacology

Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Cisplatin Absorption

No information avaliable

Cisplatin side effects and Toxicity

No information avaliable

Cisplatin Patient Information

No information avaliable

Cisplatin Organisms Affected

Humans and other mammals