PharmacyCodes



Cisplatine en es it fr

Cisplatine Brand names, Cisplatine Analogs

Cisplatine Brand Names Mixture

  • No information avaliable

Cisplatine Chemical_Formula

Cl2H4N2Pt

Cisplatine RX_link

http://www.rxlist.com/cgi/generic3/cisplatin.htm

Cisplatine fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=71

Cisplatine msds (material safety sheet)

Cisplatine MSDS

Cisplatine Synthesis Reference

No information avaliable

Cisplatine Molecular Weight

298.029 g/mol

Cisplatine Melting Point

270 oC

Cisplatine H2O Solubility

2530 mg/L

Cisplatine State

Solid

Cisplatine LogP

-2.19

Cisplatine Dosage Forms

Solution

Cisplatine Indication

For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.

Cisplatine Pharmacology

Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Cisplatine Absorption

No information avaliable

Cisplatine side effects and Toxicity

No information avaliable

Cisplatine Patient Information

No information avaliable

Cisplatine Organisms Affected

Humans and other mammals