Platinum Diamine Dichloride
Brand names,
Platinum Diamine Dichloride
Analogs
Platinum Diamine Dichloride
Brand Names Mixture
Platinum Diamine Dichloride
Chemical_Formula
Cl2H4N2Pt
Platinum Diamine Dichloride
RX_link
http://www.rxlist.com/cgi/generic3/cisplatin.htm
Platinum Diamine Dichloride
fda sheet
Platinum Diamine Dichloride
msds (material safety sheet)
Platinum Diamine Dichloride
Synthesis Reference
No information avaliable
Platinum Diamine Dichloride
Molecular Weight
298.029 g/mol
Platinum Diamine Dichloride
Melting Point
270 oC
Platinum Diamine Dichloride
H2O Solubility
2530 mg/L
Platinum Diamine Dichloride
State
Solid
Platinum Diamine Dichloride
LogP
-2.19
Platinum Diamine Dichloride
Dosage Forms
Solution
Platinum Diamine Dichloride
Indication
For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Platinum Diamine Dichloride
Pharmacology
Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Platinum Diamine Dichloride
Absorption
No information avaliable
Platinum Diamine Dichloride
side effects and Toxicity
No information avaliable
Platinum Diamine Dichloride
Patient Information
No information avaliable
Platinum Diamine Dichloride
Organisms Affected
Humans and other mammals