Cis-Ddp
Brand names,
Cis-Ddp
Analogs
Cis-Ddp
Brand Names Mixture
Cis-Ddp
Chemical_Formula
Cl2H4N2Pt
Cis-Ddp
RX_link
http://www.rxlist.com/cgi/generic3/cisplatin.htm
Cis-Ddp
fda sheet
Cis-Ddp
msds (material safety sheet)
Cis-Ddp
Synthesis Reference
No information avaliable
Cis-Ddp
Molecular Weight
298.029 g/mol
Cis-Ddp
Melting Point
270 oC
Cis-Ddp
H2O Solubility
2530 mg/L
Cis-Ddp
State
Solid
Cis-Ddp
LogP
-2.19
Cis-Ddp
Dosage Forms
Solution
Cis-Ddp
Indication
For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Cis-Ddp
Pharmacology
Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Cis-Ddp
Absorption
No information avaliable
Cis-Ddp
side effects and Toxicity
No information avaliable
Cis-Ddp
Patient Information
No information avaliable
Cis-Ddp
Organisms Affected
Humans and other mammals