Platinum Ammonium Chloride
Brand names,
Platinum Ammonium Chloride
Analogs
Platinum Ammonium Chloride
Brand Names Mixture
Platinum Ammonium Chloride
Chemical_Formula
Cl2H4N2Pt
Platinum Ammonium Chloride
RX_link
http://www.rxlist.com/cgi/generic3/cisplatin.htm
Platinum Ammonium Chloride
fda sheet
Platinum Ammonium Chloride
msds (material safety sheet)
Platinum Ammonium Chloride
Synthesis Reference
No information avaliable
Platinum Ammonium Chloride
Molecular Weight
298.029 g/mol
Platinum Ammonium Chloride
Melting Point
270 oC
Platinum Ammonium Chloride
H2O Solubility
2530 mg/L
Platinum Ammonium Chloride
State
Solid
Platinum Ammonium Chloride
LogP
-2.19
Platinum Ammonium Chloride
Dosage Forms
Solution
Platinum Ammonium Chloride
Indication
For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Platinum Ammonium Chloride
Pharmacology
Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Platinum Ammonium Chloride
Absorption
No information avaliable
Platinum Ammonium Chloride
side effects and Toxicity
No information avaliable
Platinum Ammonium Chloride
Patient Information
No information avaliable
Platinum Ammonium Chloride
Organisms Affected
Humans and other mammals