PharmacyCodes



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Briplatin Brand names, Briplatin Analogs

Briplatin Brand Names Mixture

  • No information avaliable

Briplatin Chemical_Formula

Cl2H4N2Pt

Briplatin RX_link

http://www.rxlist.com/cgi/generic3/cisplatin.htm

Briplatin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=71

Briplatin msds (material safety sheet)

Briplatin MSDS

Briplatin Synthesis Reference

No information avaliable

Briplatin Molecular Weight

298.029 g/mol

Briplatin Melting Point

270 oC

Briplatin H2O Solubility

2530 mg/L

Briplatin State

Solid

Briplatin LogP

-2.19

Briplatin Dosage Forms

Solution

Briplatin Indication

For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.

Briplatin Pharmacology

Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Briplatin Absorption

No information avaliable

Briplatin side effects and Toxicity

No information avaliable

Briplatin Patient Information

No information avaliable

Briplatin Organisms Affected

Humans and other mammals