Tisomycin
Tisomycin Brand names, Tisomycin Analogs
- Cicloserina
- Closerin
- Closina
- Cyclomycin
- Cyclorin
- Cycloserin
- Cycloserine, D-
- D-CS
- D-Cycloserine
- D-Cycloserine synth. BP 88
- D-Cycloserine, synthetic
- D-Oxamicina
- D-Oxamycin
- DL-Cycloserine
- Farmiserina
- Farmiserine
- L-Cycloserine
- Micoserina
- Miroserina
- Miroseryn
- Novoserin
- Orientomycin
- Oxamicina
- Oxamycin
- Oxymycin
- Seromycin
- Tebemicina
- Tisomycin
- Wasserina
- alpha-Cycloserine
Tisomycin Brand Names Mixture
- No information avaliable
Tisomycin Chemical_Formula
C3H6N2O2
Tisomycin RX_link
No information avaliable
Tisomycin fda sheet
Tisomycin msds (material safety sheet)
Tisomycin Synthesis Reference
No information avaliable
Tisomycin Molecular Weight
102.092 g/mol
Tisomycin Melting Point
147 oC
Tisomycin H2O Solubility
Soluble
Tisomycin State
Solid
Tisomycin LogP
-1.631
Tisomycin Dosage Forms
Capsules (red and gray capsules, oral, 250mg)
Tisomycin Indication
Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
Tisomycin Pharmacology
Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Cycloserine works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria
Tisomycin Absorption
Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.
Tisomycin side effects and Toxicity
Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.
Tisomycin Patient Information
Tisomycin Organisms Affected
Enteric bacteria and other eubacteria
