Kato
Brand names,
Kato
Analogs
Kato
Brand Names Mixture
Kato
Chemical_Formula
C26H28N2
Kato
RX_link
No information avaliable
Kato
fda sheet
Kato
msds (material safety sheet)
Kato
Synthesis Reference
No information avaliable
Kato
Molecular Weight
368.514 g/mol
Kato
Melting Point
No information avaliable
Kato
H2O Solubility
750 mg/L
Kato
State
Solid
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LogP
5.63
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Dosage Forms
No information avaliable
Kato
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Kato
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Kato
Absorption
No information avaliable
Kato
side effects and Toxicity
No information avaliable
Kato
Patient Information
No information avaliable
Kato
Organisms Affected
Humans and other mammals