Abitrate
Brand names,
Abitrate
Analogs
Abitrate
Brand Names Mixture
Abitrate
Chemical_Formula
C26H28N2
Abitrate
RX_link
No information avaliable
Abitrate
fda sheet
Abitrate
msds (material safety sheet)
Abitrate
Synthesis Reference
No information avaliable
Abitrate
Molecular Weight
368.514 g/mol
Abitrate
Melting Point
No information avaliable
Abitrate
H2O Solubility
750 mg/L
Abitrate
State
Solid
Abitrate
LogP
5.63
Abitrate
Dosage Forms
No information avaliable
Abitrate
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Abitrate
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Abitrate
Absorption
No information avaliable
Abitrate
side effects and Toxicity
No information avaliable
Abitrate
Patient Information
No information avaliable
Abitrate
Organisms Affected
Humans and other mammals