Aplexal
Brand names,
Aplexal
Analogs
Aplexal
Brand Names Mixture
Aplexal
Chemical_Formula
C26H28N2
Aplexal
RX_link
No information avaliable
Aplexal
fda sheet
Aplexal
msds (material safety sheet)
Aplexal
Synthesis Reference
No information avaliable
Aplexal
Molecular Weight
368.514 g/mol
Aplexal
Melting Point
No information avaliable
Aplexal
H2O Solubility
750 mg/L
Aplexal
State
Solid
Aplexal
LogP
5.63
Aplexal
Dosage Forms
No information avaliable
Aplexal
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Aplexal
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Aplexal
Absorption
No information avaliable
Aplexal
side effects and Toxicity
No information avaliable
Aplexal
Patient Information
No information avaliable
Aplexal
Organisms Affected
Humans and other mammals