Sepan
Brand names,
Sepan
Analogs
Sepan
Brand Names Mixture
Sepan
Chemical_Formula
C26H28N2
Sepan
RX_link
No information avaliable
Sepan
fda sheet
Sepan
msds (material safety sheet)
Sepan
Synthesis Reference
No information avaliable
Sepan
Molecular Weight
368.514 g/mol
Sepan
Melting Point
No information avaliable
Sepan
H2O Solubility
750 mg/L
Sepan
State
Solid
Sepan
LogP
5.63
Sepan
Dosage Forms
No information avaliable
Sepan
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Sepan
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Sepan
Absorption
No information avaliable
Sepan
side effects and Toxicity
No information avaliable
Sepan
Patient Information
No information avaliable
Sepan
Organisms Affected
Humans and other mammals