Spaderizine
Brand names,
Spaderizine
Analogs
Spaderizine
Brand Names Mixture
Spaderizine
Chemical_Formula
C26H28N2
Spaderizine
RX_link
No information avaliable
Spaderizine
fda sheet
Spaderizine
msds (material safety sheet)
Spaderizine
Synthesis Reference
No information avaliable
Spaderizine
Molecular Weight
368.514 g/mol
Spaderizine
Melting Point
No information avaliable
Spaderizine
H2O Solubility
750 mg/L
Spaderizine
State
Solid
Spaderizine
LogP
5.63
Spaderizine
Dosage Forms
No information avaliable
Spaderizine
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Spaderizine
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Spaderizine
Absorption
No information avaliable
Spaderizine
side effects and Toxicity
No information avaliable
Spaderizine
Patient Information
No information avaliable
Spaderizine
Organisms Affected
Humans and other mammals