Aplactan
Brand names,
Aplactan
Analogs
Aplactan
Brand Names Mixture
Aplactan
Chemical_Formula
C26H28N2
Aplactan
RX_link
No information avaliable
Aplactan
fda sheet
Aplactan
msds (material safety sheet)
Aplactan
Synthesis Reference
No information avaliable
Aplactan
Molecular Weight
368.514 g/mol
Aplactan
Melting Point
No information avaliable
Aplactan
H2O Solubility
750 mg/L
Aplactan
State
Solid
Aplactan
LogP
5.63
Aplactan
Dosage Forms
No information avaliable
Aplactan
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Aplactan
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Aplactan
Absorption
No information avaliable
Aplactan
side effects and Toxicity
No information avaliable
Aplactan
Patient Information
No information avaliable
Aplactan
Organisms Affected
Humans and other mammals