Toliman
Brand names,
Toliman
Analogs
Toliman
Brand Names Mixture
Toliman
Chemical_Formula
C26H28N2
Toliman
RX_link
No information avaliable
Toliman
fda sheet
Toliman
msds (material safety sheet)
Toliman
Synthesis Reference
No information avaliable
Toliman
Molecular Weight
368.514 g/mol
Toliman
Melting Point
No information avaliable
Toliman
H2O Solubility
750 mg/L
Toliman
State
Solid
Toliman
LogP
5.63
Toliman
Dosage Forms
No information avaliable
Toliman
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Toliman
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Toliman
Absorption
No information avaliable
Toliman
side effects and Toxicity
No information avaliable
Toliman
Patient Information
No information avaliable
Toliman
Organisms Affected
Humans and other mammals