Cinnarizine
Brand names,
Cinnarizine
Analogs
Cinnarizine
Brand Names Mixture
Cinnarizine
Chemical_Formula
C26H28N2
Cinnarizine
RX_link
No information avaliable
Cinnarizine
fda sheet
Cinnarizine
msds (material safety sheet)
Cinnarizine
Synthesis Reference
No information avaliable
Cinnarizine
Molecular Weight
368.514 g/mol
Cinnarizine
Melting Point
No information avaliable
Cinnarizine
H2O Solubility
750 mg/L
Cinnarizine
State
Solid
Cinnarizine
LogP
5.63
Cinnarizine
Dosage Forms
No information avaliable
Cinnarizine
Indication
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Cinnarizine
Pharmacology
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Cinnarizine
Absorption
No information avaliable
Cinnarizine
side effects and Toxicity
No information avaliable
Cinnarizine
Patient Information
No information avaliable
Cinnarizine
Organisms Affected
Humans and other mammals