Nystatin
Nystatin Brand names, Nystatin Analogs
Nystatin Brand Names Mixture
- No information avaliable
Nystatin Chemical_Formula
C47H75NO17
Nystatin RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Nystatin fda sheet
Nystatin msds (material safety sheet)
Nystatin Synthesis Reference
No information avaliable
Nystatin Molecular Weight
926.09 g/mol
Nystatin Melting Point
160oC
Nystatin H2O Solubility
360 mg/L
Nystatin State
Solid
Nystatin LogP
-0.534
Nystatin Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Nystatin Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Nystatin Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Nystatin Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Nystatin side effects and Toxicity
No information avaliable
Nystatin Patient Information
No information avaliable
Nystatin Organisms Affected
Fungi
