Nilstat
Nilstat Brand names, Nilstat Analogs
Nilstat Brand Names Mixture
- No information avaliable
Nilstat Chemical_Formula
C47H75NO17
Nilstat RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Nilstat fda sheet
Nilstat msds (material safety sheet)
Nilstat Synthesis Reference
No information avaliable
Nilstat Molecular Weight
926.09 g/mol
Nilstat Melting Point
160oC
Nilstat H2O Solubility
360 mg/L
Nilstat State
Solid
Nilstat LogP
-0.534
Nilstat Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Nilstat Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Nilstat Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Nilstat Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Nilstat side effects and Toxicity
No information avaliable
Nilstat Patient Information
No information avaliable
Nilstat Organisms Affected
Fungi
