Korostatin
Korostatin Brand names, Korostatin Analogs
Korostatin Brand Names Mixture
- No information avaliable
Korostatin Chemical_Formula
C47H75NO17
Korostatin RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Korostatin fda sheet
Korostatin msds (material safety sheet)
Korostatin Synthesis Reference
No information avaliable
Korostatin Molecular Weight
926.09 g/mol
Korostatin Melting Point
160oC
Korostatin H2O Solubility
360 mg/L
Korostatin State
Solid
Korostatin LogP
-0.534
Korostatin Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Korostatin Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Korostatin Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Korostatin Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Korostatin side effects and Toxicity
No information avaliable
Korostatin Patient Information
No information avaliable
Korostatin Organisms Affected
Fungi
