Candex
Candex Brand names, Candex Analogs
Candex Brand Names Mixture
- No information avaliable
Candex Chemical_Formula
C47H75NO17
Candex RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Candex fda sheet
Candex msds (material safety sheet)
Candex Synthesis Reference
No information avaliable
Candex Molecular Weight
926.09 g/mol
Candex Melting Point
160oC
Candex H2O Solubility
360 mg/L
Candex State
Solid
Candex LogP
-0.534
Candex Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Candex Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Candex Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Candex Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Candex side effects and Toxicity
No information avaliable
Candex Patient Information
No information avaliable
Candex Organisms Affected
Fungi
