Nadostine
Nadostine Brand names, Nadostine Analogs
Nadostine Brand Names Mixture
- No information avaliable
Nadostine Chemical_Formula
C47H75NO17
Nadostine RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Nadostine fda sheet
Nadostine msds (material safety sheet)
Nadostine Synthesis Reference
No information avaliable
Nadostine Molecular Weight
926.09 g/mol
Nadostine Melting Point
160oC
Nadostine H2O Solubility
360 mg/L
Nadostine State
Solid
Nadostine LogP
-0.534
Nadostine Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Nadostine Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Nadostine Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Nadostine Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Nadostine side effects and Toxicity
No information avaliable
Nadostine Patient Information
No information avaliable
Nadostine Organisms Affected
Fungi
