Mykacet
Mykacet Brand names, Mykacet Analogs
Mykacet Brand Names Mixture
- No information avaliable
Mykacet Chemical_Formula
C47H75NO17
Mykacet RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Mykacet fda sheet
Mykacet msds (material safety sheet)
Mykacet Synthesis Reference
No information avaliable
Mykacet Molecular Weight
926.09 g/mol
Mykacet Melting Point
160oC
Mykacet H2O Solubility
360 mg/L
Mykacet State
Solid
Mykacet LogP
-0.534
Mykacet Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Mykacet Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Mykacet Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Mykacet Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Mykacet side effects and Toxicity
No information avaliable
Mykacet Patient Information
No information avaliable
Mykacet Organisms Affected
Fungi
