Mykinac
Mykinac Brand names, Mykinac Analogs
Mykinac Brand Names Mixture
- No information avaliable
Mykinac Chemical_Formula
C47H75NO17
Mykinac RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Mykinac fda sheet
Mykinac msds (material safety sheet)
Mykinac Synthesis Reference
No information avaliable
Mykinac Molecular Weight
926.09 g/mol
Mykinac Melting Point
160oC
Mykinac H2O Solubility
360 mg/L
Mykinac State
Solid
Mykinac LogP
-0.534
Mykinac Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Mykinac Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Mykinac Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Mykinac Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Mykinac side effects and Toxicity
No information avaliable
Mykinac Patient Information
No information avaliable
Mykinac Organisms Affected
Fungi
