Hidrix
Hidrix Brand names, Hidrix Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
Hidrix Brand Names Mixture
- No information avaliable
Hidrix Chemical_Formula
CH4N2O2
Hidrix RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Hidrix fda sheet
Hidrix msds (material safety sheet)
Hidrix Synthesis Reference
No information avaliable
Hidrix Molecular Weight
76.0547 g/mol
Hidrix Melting Point
142-146 oC
Hidrix H2O Solubility
1E+006 mg/L
Hidrix State
Solid
Hidrix LogP
-1.432
Hidrix Dosage Forms
Capsule
Hidrix Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hidrix Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Hidrix Absorption
Well absorbed from the gastrointestinal tract.
Hidrix side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hidrix Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
Hidrix Organisms Affected
Humans and other mammals
