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Hidrix Brand names, Hidrix Analogs

Hidrix Brand Names Mixture

  • No information avaliable

Hidrix Chemical_Formula

CH4N2O2

Hidrix RX_link

http://www.rxlist.com/cgi/generic2/hydroxyurea.htm

Hidrix fda sheet

Hidrix FDA

Hidrix msds (material safety sheet)

Hidrix MSDS

Hidrix Synthesis Reference

No information avaliable

Hidrix Molecular Weight

76.0547 g/mol

Hidrix Melting Point

142-146 oC

Hidrix H2O Solubility

1E+006 mg/L

Hidrix State

Solid

Hidrix LogP

-1.432

Hidrix Dosage Forms

Capsule

Hidrix Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Hidrix Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Hidrix Absorption

Well absorbed from the gastrointestinal tract.

Hidrix side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Hidrix Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Hidrix Organisms Affected

Humans and other mammals