Hydroxylurea en es it fr

Hydroxylurea Brand names, Hydroxylurea Analogs

Hydroxylurea Brand Names Mixture

  • No information avaliable

Hydroxylurea Chemical_Formula


Hydroxylurea RX_link


Hydroxylurea fda sheet

Hydroxylurea FDA

Hydroxylurea msds (material safety sheet)

Hydroxylurea MSDS

Hydroxylurea Synthesis Reference

No information avaliable

Hydroxylurea Molecular Weight

76.0547 g/mol

Hydroxylurea Melting Point

142-146 oC

Hydroxylurea H2O Solubility

1E+006 mg/L

Hydroxylurea State


Hydroxylurea LogP


Hydroxylurea Dosage Forms


Hydroxylurea Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Hydroxylurea Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Hydroxylurea Absorption

Well absorbed from the gastrointestinal tract.

Hydroxylurea side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Hydroxylurea Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Hydroxylurea Organisms Affected

Humans and other mammals