Hydroxycarbamine
Hydroxycarbamine Brand names, Hydroxycarbamine Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
Hydroxycarbamine Brand Names Mixture
- No information avaliable
Hydroxycarbamine Chemical_Formula
CH4N2O2
Hydroxycarbamine RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Hydroxycarbamine fda sheet
Hydroxycarbamine msds (material safety sheet)
Hydroxycarbamine Synthesis Reference
No information avaliable
Hydroxycarbamine Molecular Weight
76.0547 g/mol
Hydroxycarbamine Melting Point
142-146 oC
Hydroxycarbamine H2O Solubility
1E+006 mg/L
Hydroxycarbamine State
Solid
Hydroxycarbamine LogP
-1.432
Hydroxycarbamine Dosage Forms
Capsule
Hydroxycarbamine Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydroxycarbamine Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Hydroxycarbamine Absorption
Well absorbed from the gastrointestinal tract.
Hydroxycarbamine side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hydroxycarbamine Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
Hydroxycarbamine Organisms Affected
Humans and other mammals
