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Hydroxycarbamine Brand names, Hydroxycarbamine Analogs

Hydroxycarbamine Brand Names Mixture

  • No information avaliable

Hydroxycarbamine Chemical_Formula


Hydroxycarbamine RX_link


Hydroxycarbamine fda sheet

Hydroxycarbamine FDA

Hydroxycarbamine msds (material safety sheet)

Hydroxycarbamine MSDS

Hydroxycarbamine Synthesis Reference

No information avaliable

Hydroxycarbamine Molecular Weight

76.0547 g/mol

Hydroxycarbamine Melting Point

142-146 oC

Hydroxycarbamine H2O Solubility

1E+006 mg/L

Hydroxycarbamine State


Hydroxycarbamine LogP


Hydroxycarbamine Dosage Forms


Hydroxycarbamine Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Hydroxycarbamine Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Hydroxycarbamine Absorption

Well absorbed from the gastrointestinal tract.

Hydroxycarbamine side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Hydroxycarbamine Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Hydroxycarbamine Organisms Affected

Humans and other mammals