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Carbamoyl Oxime Brand names, Carbamoyl Oxime Analogs

Carbamoyl Oxime Brand Names Mixture

  • No information avaliable

Carbamoyl Oxime Chemical_Formula


Carbamoyl Oxime RX_link

Carbamoyl Oxime fda sheet

Carbamoyl_Oxime FDA

Carbamoyl Oxime msds (material safety sheet)

Carbamoyl_Oxime MSDS

Carbamoyl Oxime Synthesis Reference

No information avaliable

Carbamoyl Oxime Molecular Weight

76.0547 g/mol

Carbamoyl Oxime Melting Point

142-146 oC

Carbamoyl Oxime H2O Solubility

1E+006 mg/L

Carbamoyl Oxime State


Carbamoyl Oxime LogP


Carbamoyl Oxime Dosage Forms


Carbamoyl Oxime Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Carbamoyl Oxime Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Carbamoyl Oxime Absorption

Well absorbed from the gastrointestinal tract.

Carbamoyl Oxime side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Carbamoyl Oxime Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Carbamoyl Oxime Organisms Affected

Humans and other mammals