Carbamoyl Oxime
Carbamoyl Oxime Brand names, Carbamoyl Oxime Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
Carbamoyl Oxime Brand Names Mixture
- No information avaliable
Carbamoyl Oxime Chemical_Formula
CH4N2O2
Carbamoyl Oxime RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Carbamoyl Oxime fda sheet
Carbamoyl Oxime msds (material safety sheet)
Carbamoyl Oxime Synthesis Reference
No information avaliable
Carbamoyl Oxime Molecular Weight
76.0547 g/mol
Carbamoyl Oxime Melting Point
142-146 oC
Carbamoyl Oxime H2O Solubility
1E+006 mg/L
Carbamoyl Oxime State
Solid
Carbamoyl Oxime LogP
-1.432
Carbamoyl Oxime Dosage Forms
Capsule
Carbamoyl Oxime Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Carbamoyl Oxime Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Carbamoyl Oxime Absorption
Well absorbed from the gastrointestinal tract.
Carbamoyl Oxime side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Carbamoyl Oxime Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
Carbamoyl Oxime Organisms Affected
Humans and other mammals
