N-Hydroxyurea
N-Hydroxyurea Brand names, N-Hydroxyurea Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
N-Hydroxyurea Brand Names Mixture
- No information avaliable
N-Hydroxyurea Chemical_Formula
CH4N2O2
N-Hydroxyurea RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
N-Hydroxyurea fda sheet
N-Hydroxyurea msds (material safety sheet)
N-Hydroxyurea Synthesis Reference
No information avaliable
N-Hydroxyurea Molecular Weight
76.0547 g/mol
N-Hydroxyurea Melting Point
142-146 oC
N-Hydroxyurea H2O Solubility
1E+006 mg/L
N-Hydroxyurea State
Solid
N-Hydroxyurea LogP
-1.432
N-Hydroxyurea Dosage Forms
Capsule
N-Hydroxyurea Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
N-Hydroxyurea Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
N-Hydroxyurea Absorption
Well absorbed from the gastrointestinal tract.
N-Hydroxyurea side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
N-Hydroxyurea Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
N-Hydroxyurea Organisms Affected
Humans and other mammals
