N-Hydroxyurea en es it fr

N-Hydroxyurea Brand names, N-Hydroxyurea Analogs

N-Hydroxyurea Brand Names Mixture

  • No information avaliable

N-Hydroxyurea Chemical_Formula


N-Hydroxyurea RX_link


N-Hydroxyurea fda sheet

N-Hydroxyurea FDA

N-Hydroxyurea msds (material safety sheet)

N-Hydroxyurea MSDS

N-Hydroxyurea Synthesis Reference

No information avaliable

N-Hydroxyurea Molecular Weight

76.0547 g/mol

N-Hydroxyurea Melting Point

142-146 oC

N-Hydroxyurea H2O Solubility

1E+006 mg/L

N-Hydroxyurea State


N-Hydroxyurea LogP


N-Hydroxyurea Dosage Forms


N-Hydroxyurea Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

N-Hydroxyurea Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

N-Hydroxyurea Absorption

Well absorbed from the gastrointestinal tract.

N-Hydroxyurea side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

N-Hydroxyurea Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

N-Hydroxyurea Organisms Affected

Humans and other mammals