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Hydroxicarbamidum Brand names, Hydroxicarbamidum Analogs

Hydroxicarbamidum Brand Names Mixture

  • No information avaliable

Hydroxicarbamidum Chemical_Formula


Hydroxicarbamidum RX_link


Hydroxicarbamidum fda sheet

Hydroxicarbamidum FDA

Hydroxicarbamidum msds (material safety sheet)

Hydroxicarbamidum MSDS

Hydroxicarbamidum Synthesis Reference

No information avaliable

Hydroxicarbamidum Molecular Weight

76.0547 g/mol

Hydroxicarbamidum Melting Point

142-146 oC

Hydroxicarbamidum H2O Solubility

1E+006 mg/L

Hydroxicarbamidum State


Hydroxicarbamidum LogP


Hydroxicarbamidum Dosage Forms


Hydroxicarbamidum Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Hydroxicarbamidum Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Hydroxicarbamidum Absorption

Well absorbed from the gastrointestinal tract.

Hydroxicarbamidum side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Hydroxicarbamidum Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Hydroxicarbamidum Organisms Affected

Humans and other mammals