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HU Brand names, HU Analogs

HU Brand Names Mixture

  • No information avaliable

HU Chemical_Formula


HU RX_link

HU fda sheet


HU msds (material safety sheet)


HU Synthesis Reference

No information avaliable

HU Molecular Weight

76.0547 g/mol

HU Melting Point

142-146 oC

HU H2O Solubility

1E+006 mg/L

HU State




HU Dosage Forms


HU Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

HU Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

HU Absorption

Well absorbed from the gastrointestinal tract.

HU side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

HU Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

HU Organisms Affected

Humans and other mammals