Oxyurea
Oxyurea Brand names, Oxyurea Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
Oxyurea Brand Names Mixture
- No information avaliable
Oxyurea Chemical_Formula
CH4N2O2
Oxyurea RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Oxyurea fda sheet
Oxyurea msds (material safety sheet)
Oxyurea Synthesis Reference
No information avaliable
Oxyurea Molecular Weight
76.0547 g/mol
Oxyurea Melting Point
142-146 oC
Oxyurea H2O Solubility
1E+006 mg/L
Oxyurea State
Solid
Oxyurea LogP
-1.432
Oxyurea Dosage Forms
Capsule
Oxyurea Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Oxyurea Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Oxyurea Absorption
Well absorbed from the gastrointestinal tract.
Oxyurea side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Oxyurea Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
Oxyurea Organisms Affected
Humans and other mammals
