Hydrea
Hydrea Brand names, Hydrea Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
Hydrea Brand Names Mixture
- No information avaliable
Hydrea Chemical_Formula
CH4N2O2
Hydrea RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Hydrea fda sheet
Hydrea msds (material safety sheet)
Hydrea Synthesis Reference
No information avaliable
Hydrea Molecular Weight
76.0547 g/mol
Hydrea Melting Point
142-146 oC
Hydrea H2O Solubility
1E+006 mg/L
Hydrea State
Solid
Hydrea LogP
-1.432
Hydrea Dosage Forms
Capsule
Hydrea Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydrea Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Hydrea Absorption
Well absorbed from the gastrointestinal tract.
Hydrea side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hydrea Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
Hydrea Organisms Affected
Humans and other mammals
