Litalir
Litalir Brand names, Litalir Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
Litalir Brand Names Mixture
- No information avaliable
Litalir Chemical_Formula
CH4N2O2
Litalir RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Litalir fda sheet
Litalir msds (material safety sheet)
Litalir Synthesis Reference
No information avaliable
Litalir Molecular Weight
76.0547 g/mol
Litalir Melting Point
142-146 oC
Litalir H2O Solubility
1E+006 mg/L
Litalir State
Solid
Litalir LogP
-1.432
Litalir Dosage Forms
Capsule
Litalir Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Litalir Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Litalir Absorption
Well absorbed from the gastrointestinal tract.
Litalir side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Litalir Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
Litalir Organisms Affected
Humans and other mammals
