Carbamyl Hydroxamate en es it fr

Carbamyl Hydroxamate Brand names, Carbamyl Hydroxamate Analogs

Carbamyl Hydroxamate Brand Names Mixture

  • No information avaliable

Carbamyl Hydroxamate Chemical_Formula

CH4N2O2

Carbamyl Hydroxamate RX_link

http://www.rxlist.com/cgi/generic2/hydroxyurea.htm

Carbamyl Hydroxamate fda sheet

Carbamyl_Hydroxamate FDA

Carbamyl Hydroxamate msds (material safety sheet)

Carbamyl_Hydroxamate MSDS

Carbamyl Hydroxamate Synthesis Reference

No information avaliable

Carbamyl Hydroxamate Molecular Weight

76.0547 g/mol

Carbamyl Hydroxamate Melting Point

142-146 oC

Carbamyl Hydroxamate H2O Solubility

1E+006 mg/L

Carbamyl Hydroxamate State

Solid

Carbamyl Hydroxamate LogP

-1.432

Carbamyl Hydroxamate Dosage Forms

Capsule

Carbamyl Hydroxamate Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Carbamyl Hydroxamate Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Carbamyl Hydroxamate Absorption

Well absorbed from the gastrointestinal tract.

Carbamyl Hydroxamate side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Carbamyl Hydroxamate Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Carbamyl Hydroxamate Organisms Affected

Humans and other mammals