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Ureaphil Brand names, Ureaphil Analogs

Ureaphil Brand Names Mixture

  • No information avaliable

Ureaphil Chemical_Formula


Ureaphil RX_link


Ureaphil fda sheet

Ureaphil FDA

Ureaphil msds (material safety sheet)

Ureaphil MSDS

Ureaphil Synthesis Reference

No information avaliable

Ureaphil Molecular Weight

76.0547 g/mol

Ureaphil Melting Point

142-146 oC

Ureaphil H2O Solubility

1E+006 mg/L

Ureaphil State


Ureaphil LogP


Ureaphil Dosage Forms


Ureaphil Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Ureaphil Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Ureaphil Absorption

Well absorbed from the gastrointestinal tract.

Ureaphil side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Ureaphil Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Ureaphil Organisms Affected

Humans and other mammals