Hidrix
Material Safety Data Sheet
Hydroxyurea, 98%
ACC# 01002
Section 1 - Chemical Product and Company Identification |
MSDS Name: Hydroxyurea, 98%
Catalog Numbers:
AC151680000, AC151680050, AC151680250, AC9969169, XXAC15168-1K
Synonyms:
Hydroxycarbamide
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
127-07-1 |
Hydroxyurea |
98 | 204-821-7 |
Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white to off-white crystalline powder.
Warning! May cause eye and skin irritation. May
cause respiratory and digestive tract irritation. May cause blood
abnormalities. May cause bone marrow depression.
Target Organs: Blood, bone marrow.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May cause dermatitis.
Ingestion:
May cause bone marrow depression. Ingestion of large amounts may
cause nausea and vomiting, which can produce dehydration, internal
organ congestion and possibly coma. May cause microcytosis (smaller
than normal red blood cells), normocytic anemia (reduced red blood
cell count), luekopenia(reduced white blood cell count),
thrombocytopenia (decreased number of blood platelets) and other
blood abnormalities.
Inhalation:
Inhalation of dust may cause respiratory tract irritation.
Chronic:
Laboratory experiments have resulted in mutagenic effects. This
substance has caused adverse reproductive and fetal effects in
laboratory animals.
Hydroxyurea inhibits DNA synthesis in humans. High or repeated
exposure may affect the liver and kidney and damage the central
nervous system as well as cause hair loss and skin rashes.
Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 0; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Provide ventilation.
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Minimize dust
generation and accumulation. Avoid contact with eyes, skin, and
clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible
substances. Keep containers tightly closed.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Hydroxyurea
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
Hydroxyurea:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
|
Physical State: Crystalline powder
Appearance: white to off-white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:144.00 - 146.00 deg C
Decomposition Temperature:Not available.
Solubility: freely soluble in water
Specific Gravity/Density:Not available.
Molecular Formula:CH4N2O2
Molecular Weight:76.04
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 127-07-1:
YT4900000
LD50/LC50:
CAS# 127-07-1:
Oral, mouse: LD50 =
7330 mg/kg;
Oral, rat: LD50 = 5760
mg/kg;
.
Carcinogenicity:
CAS# 127-07-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
Teratogenic effects have occurred in experimental
animals.Hydroxyurea use during a small number of human
pregnancies has been reported. Adverse effects have not
been observed in any of the exposed newborns.
Reproductive Effects:
Adverse reproductive effects have occurred in experimental
animals.
Mutagenicity:
Mutagenic effects have occurred in experimental
animals.Mutagenic effects have occurred in humans.
Neurotoxicity:
No information found
Other Studies:
Section 12 - Ecological Information
|
No information available.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
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|
US DOT |
Canada TDG |
Shipping Name: |
Not regulated as a hazardous material |
No information available. |
Hazard Class: |
|
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UN Number: |
|
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Packing Group: |
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Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 127-07-1 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 127-07-1 can be found on the
following state right to know lists: New Jersey.
California Prop 65
WARNING: This product contains Hydroxyurea, a chemical known to the
state of California to cause developmental reproductive toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 33 Danger of cumulative effects.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 127-07-1: 1
Canada - DSL/NDSL
CAS# 127-07-1 is listed on Canada's DSL List.
Canada - WHMIS
WHMIS: Not available.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
|
MSDS Creation Date: 6/24/1998
Revision #4 Date: 2/04/2004
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.