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Carbamohydroximic Acid Brand names, Carbamohydroximic Acid Analogs

Carbamohydroximic Acid Brand Names Mixture

  • No information avaliable

Carbamohydroximic Acid Chemical_Formula

CH4N2O2

Carbamohydroximic Acid RX_link

http://www.rxlist.com/cgi/generic2/hydroxyurea.htm

Carbamohydroximic Acid fda sheet

Carbamohydroximic_Acid FDA

Carbamohydroximic Acid msds (material safety sheet)

Carbamohydroximic_Acid MSDS

Carbamohydroximic Acid Synthesis Reference

No information avaliable

Carbamohydroximic Acid Molecular Weight

76.0547 g/mol

Carbamohydroximic Acid Melting Point

142-146 oC

Carbamohydroximic Acid H2O Solubility

1E+006 mg/L

Carbamohydroximic Acid State

Solid

Carbamohydroximic Acid LogP

-1.432

Carbamohydroximic Acid Dosage Forms

Capsule

Carbamohydroximic Acid Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Carbamohydroximic Acid Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Carbamohydroximic Acid Absorption

Well absorbed from the gastrointestinal tract.

Carbamohydroximic Acid side effects and Toxicity

Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg

Carbamohydroximic Acid Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Carbamohydroximic Acid Organisms Affected

Humans and other mammals