Carbamohydroximic Acid
Carbamohydroximic Acid Brand names, Carbamohydroximic Acid Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
Carbamohydroximic Acid Brand Names Mixture
- No information avaliable
Carbamohydroximic Acid Chemical_Formula
CH4N2O2
Carbamohydroximic Acid RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Carbamohydroximic Acid fda sheet
Carbamohydroximic Acid msds (material safety sheet)
Carbamohydroximic Acid Synthesis Reference
No information avaliable
Carbamohydroximic Acid Molecular Weight
76.0547 g/mol
Carbamohydroximic Acid Melting Point
142-146 oC
Carbamohydroximic Acid H2O Solubility
1E+006 mg/L
Carbamohydroximic Acid State
Solid
Carbamohydroximic Acid LogP
-1.432
Carbamohydroximic Acid Dosage Forms
Capsule
Carbamohydroximic Acid Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Carbamohydroximic Acid Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Carbamohydroximic Acid Absorption
Well absorbed from the gastrointestinal tract.
Carbamohydroximic Acid side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Carbamohydroximic Acid Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
Carbamohydroximic Acid Organisms Affected
Humans and other mammals
