N-Carbamoylhydroxylamine
N-Carbamoylhydroxylamine Brand names, N-Carbamoylhydroxylamine Analogs
- Biosupressin
- Carbamohydroxamic Acid
- Carbamohydroximic Acid
- Carbamohydroxyamic Acid
- Carbamoyl Oxime
- Carbamyl Hydroxamate
- Droxia
- HU
- Hidrix
- Hydrea
- Hydreia
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamine
- Hydroxylurea
- Hydura
- Hydurea
- Idrossicarbamide [Dcit]
- Litaler
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxyurea
- Onco-Carbide
- Oxyurea
- Sterile Urea
- Ureaphil
N-Carbamoylhydroxylamine Brand Names Mixture
- No information avaliable
N-Carbamoylhydroxylamine Chemical_Formula
CH4N2O2
N-Carbamoylhydroxylamine RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
N-Carbamoylhydroxylamine fda sheet
N-Carbamoylhydroxylamine msds (material safety sheet)
N-Carbamoylhydroxylamine Synthesis Reference
No information avaliable
N-Carbamoylhydroxylamine Molecular Weight
76.0547 g/mol
N-Carbamoylhydroxylamine Melting Point
142-146 oC
N-Carbamoylhydroxylamine H2O Solubility
1E+006 mg/L
N-Carbamoylhydroxylamine State
Solid
N-Carbamoylhydroxylamine LogP
-1.432
N-Carbamoylhydroxylamine Dosage Forms
Capsule
N-Carbamoylhydroxylamine Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
N-Carbamoylhydroxylamine Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
N-Carbamoylhydroxylamine Absorption
Well absorbed from the gastrointestinal tract.
N-Carbamoylhydroxylamine side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
N-Carbamoylhydroxylamine Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.
N-Carbamoylhydroxylamine Organisms Affected
Humans and other mammals
