Cimetidine
Cimetidine Brand names, Cimetidine Analogs
Cimetidine Brand Names Mixture
- No information avaliable
Cimetidine Chemical_Formula
C10H16N6S
Cimetidine RX_link
http://www.rxlist.com/cgi/generic/cimet.htm
Cimetidine fda sheet
Cimetidine msds (material safety sheet)
Cimetidine Synthesis Reference
G. J. Durant et al.; U.S. Pat. 3,950,333 (1976)
Cimetidine Molecular Weight
252.34 g/mol
Cimetidine Melting Point
142 oC
Cimetidine H2O Solubility
0.5 g/100 mL
Cimetidine State
Solid
Cimetidine LogP
0.879
Cimetidine Dosage Forms
Tablets; Oral solution
Cimetidine Indication
For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion
Cimetidine Pharmacology
Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Cimetidine Absorption
Rapid 60-70%
Cimetidine side effects and Toxicity
nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
Cimetidine Patient Information
Cimetidine Organisms Affected
Humans and other mammals
