Cimetag
Brand names,
Cimetag
Analogs
Cimetag
Brand Names Mixture
Cimetag
Chemical_Formula
C10H16N6S
Cimetag
RX_link
http://www.rxlist.com/cgi/generic/cimet.htm
Cimetag
fda sheet
Cimetag
msds (material safety sheet)
Cimetag
Synthesis Reference
G. J. Durant et al.; U.S. Pat. 3,950,333 (1976)
Cimetag
Molecular Weight
252.34 g/mol
Cimetag
Melting Point
142 oC
Cimetag
H2O Solubility
0.5 g/100 mL
Cimetag
State
Solid
Cimetag
LogP
0.879
Cimetag
Dosage Forms
Tablets; Oral solution
Cimetag
Indication
For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion
Cimetag
Pharmacology
Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Cimetag
Absorption
Rapid 60-70%
Cimetag
side effects and Toxicity
nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
Cimetag
Patient Information
Cimetag
Organisms Affected
Humans and other mammals