Gastromet
Brand names,
Gastromet
Analogs
Gastromet
Brand Names Mixture
Gastromet
Chemical_Formula
C10H16N6S
Gastromet
RX_link
http://www.rxlist.com/cgi/generic/cimet.htm
Gastromet
fda sheet
Gastromet
msds (material safety sheet)
Gastromet
Synthesis Reference
G. J. Durant et al.; U.S. Pat. 3,950,333 (1976)
Gastromet
Molecular Weight
252.34 g/mol
Gastromet
Melting Point
142 oC
Gastromet
H2O Solubility
0.5 g/100 mL
Gastromet
State
Solid
Gastromet
LogP
0.879
Gastromet
Dosage Forms
Tablets; Oral solution
Gastromet
Indication
For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion
Gastromet
Pharmacology
Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Gastromet
Absorption
Rapid 60-70%
Gastromet
side effects and Toxicity
nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
Gastromet
Patient Information
Gastromet
Organisms Affected
Humans and other mammals