Sulfonamide
Brand names,
Sulfonamide
Analogs
Sulfonamide
Brand Names Mixture
Sulfonamide
Chemical_Formula
C10H10N4O2S
Sulfonamide
RX_link
http://www.rxlist.com/cgi/generic3/silversulf.htm
Sulfonamide
fda sheet
Sulfonamide
msds (material safety sheet)
Sulfonamide
Synthesis Reference
No information avaliable
Sulfonamide
Molecular Weight
250.278 g/mol
Sulfonamide
Melting Point
No information avaliable
Sulfonamide
H2O Solubility
No information avaliable
Sulfonamide
State
Solid
Sulfonamide
LogP
1.883
Sulfonamide
Dosage Forms
Cream
Sulfonamide
Indication
For the treatment of rheumatic fever and meningococcal meningitis
Sulfonamide
Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfonamide
Absorption
No information avaliable
Sulfonamide
side effects and Toxicity
No information avaliable
Sulfonamide
Patient Information
No information avaliable
Sulfonamide
Organisms Affected
Enteric bacteria and other eubacteria