Diazolone
Brand names,
Diazolone
Analogs
Diazolone
Brand Names Mixture
Diazolone
Chemical_Formula
C10H10N4O2S
Diazolone
RX_link
http://www.rxlist.com/cgi/generic3/silversulf.htm
Diazolone
fda sheet
Diazolone
msds (material safety sheet)
Diazolone
Synthesis Reference
No information avaliable
Diazolone
Molecular Weight
250.278 g/mol
Diazolone
Melting Point
No information avaliable
Diazolone
H2O Solubility
No information avaliable
Diazolone
State
Solid
Diazolone
LogP
1.883
Diazolone
Dosage Forms
Cream
Diazolone
Indication
For the treatment of rheumatic fever and meningococcal meningitis
Diazolone
Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Diazolone
Absorption
No information avaliable
Diazolone
side effects and Toxicity
No information avaliable
Diazolone
Patient Information
No information avaliable
Diazolone
Organisms Affected
Enteric bacteria and other eubacteria