Adiazine
Brand names,
Adiazine
Analogs
Adiazine
Brand Names Mixture
Adiazine
Chemical_Formula
C10H10N4O2S
Adiazine
RX_link
http://www.rxlist.com/cgi/generic3/silversulf.htm
Adiazine
fda sheet
Adiazine
msds (material safety sheet)
Adiazine
Synthesis Reference
No information avaliable
Adiazine
Molecular Weight
250.278 g/mol
Adiazine
Melting Point
No information avaliable
Adiazine
H2O Solubility
No information avaliable
Adiazine
State
Solid
Adiazine
LogP
1.883
Adiazine
Dosage Forms
Cream
Adiazine
Indication
For the treatment of rheumatic fever and meningococcal meningitis
Adiazine
Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Adiazine
Absorption
No information avaliable
Adiazine
side effects and Toxicity
No information avaliable
Adiazine
Patient Information
No information avaliable
Adiazine
Organisms Affected
Enteric bacteria and other eubacteria