Spofadrizine
Brand names,
Spofadrizine
Analogs
Spofadrizine
Brand Names Mixture
Spofadrizine
Chemical_Formula
C10H10N4O2S
Spofadrizine
RX_link
http://www.rxlist.com/cgi/generic3/silversulf.htm
Spofadrizine
fda sheet
Spofadrizine
msds (material safety sheet)
Spofadrizine
Synthesis Reference
No information avaliable
Spofadrizine
Molecular Weight
250.278 g/mol
Spofadrizine
Melting Point
No information avaliable
Spofadrizine
H2O Solubility
No information avaliable
Spofadrizine
State
Solid
Spofadrizine
LogP
1.883
Spofadrizine
Dosage Forms
Cream
Spofadrizine
Indication
For the treatment of rheumatic fever and meningococcal meningitis
Spofadrizine
Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Spofadrizine
Absorption
No information avaliable
Spofadrizine
side effects and Toxicity
No information avaliable
Spofadrizine
Patient Information
No information avaliable
Spofadrizine
Organisms Affected
Enteric bacteria and other eubacteria