Sulfonamides Duplex
Brand names,
Sulfonamides Duplex
Analogs
Sulfonamides Duplex
Brand Names Mixture
Sulfonamides Duplex
Chemical_Formula
C10H10N4O2S
Sulfonamides Duplex
RX_link
http://www.rxlist.com/cgi/generic3/silversulf.htm
Sulfonamides Duplex
fda sheet
Sulfonamides Duplex
msds (material safety sheet)
Sulfonamides Duplex
Synthesis Reference
No information avaliable
Sulfonamides Duplex
Molecular Weight
250.278 g/mol
Sulfonamides Duplex
Melting Point
No information avaliable
Sulfonamides Duplex
H2O Solubility
No information avaliable
Sulfonamides Duplex
State
Solid
Sulfonamides Duplex
LogP
1.883
Sulfonamides Duplex
Dosage Forms
Cream
Sulfonamides Duplex
Indication
For the treatment of rheumatic fever and meningococcal meningitis
Sulfonamides Duplex
Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfonamides Duplex
Absorption
No information avaliable
Sulfonamides Duplex
side effects and Toxicity
No information avaliable
Sulfonamides Duplex
Patient Information
No information avaliable
Sulfonamides Duplex
Organisms Affected
Enteric bacteria and other eubacteria